Chronic Idiopathic Constipation (CIC. “Idiopathic” means the cause is unknown) & Irritable Bowel Syndrome with Constipation (IBS-C) are types of chronic constipation.
Research shows that when the Biological Clock is not synchronized, it may lead to constipation, among other symptoms5.
Mechanical stimulation of the colon with gentle vibrations, resynchronizes the biological clock via the ENS-CNS pathway.
When the biological clock is resynchronized, the natural bowel movement bio-rhythm is restored.
In a phase 3 clinical trial with the Vibrating capsules, patients experienced significant improvement of constipation symptoms vs placebo4.
As seen in
1. Gut inference: A computational modelling approach: July 22, 2021, Appears in: Biological Psychology
2. Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice: August 10, 2021, Appears in: Communications Biology, Nature.com
3. SLACK Incorporated, “Current Insights About Constipation: October 2018
4. Phase III patients’ post research self-reported outcomes
5. Disruption of Circadian Rhythms and Gut Motility: Journal of Clinical Gastroenterology. May/June 2020 – Volume 54 – Issue 5 – p 405-414
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