Research shows that when the Biological Clock is not synchronized, it may lead to constipation, among other symptoms.
The new mechanism of action resynchronizes the biological clock, improving daily bowel movement bio-rhythm.
Phase 3 clinical trial shows that the Vibrating capsules significantly improve constipation symptoms, provides complete bowel movements, and have no related nausea or diarrhea.
The patient places the capsule in the pod for an automatic activation
The patient swallowes the capsule with a glass of water
Clinical trials show significant constipation symptoms relief
The patient can follow & monitor the treatment using a companion app
6 multi-center clinical studies completed
137 clinical sites primarily in the US
850 chronic constipation patients
Rao SSC, Quigley EMM, Chey WD, Sharma A, Dinh D., Dunn L., Fogel R., Romero S., Teltser M. ,Morin P., Torres L., Surowitz R., Reddy V. , Wayne J., Beaulieu E., Snook M., Goldstein G., Rubino J., Freeman G., Lumicao B., Greenwald J., Shah S., Zopo A., Wild J., Hellstern P., Murray A., Usdan L., Goldstein G., Whitmer D., Oza A., Friedenberg K., Lembo A, et al
Vibrant significantly improved stool frequency, other bowel and abdominal symptoms and quality of life in patients with CIC. These benefits were seen soon after the initiation of therapy and were sustained with no significant adverse events.
Vibrant provides a novel, non-pharmacological, intraluminal therapy which is efficacious, safe and well tolerated in patients with CIC.
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1. Gut inference: A computational modelling approach: July 22, 2021, Appears in: Biological Psychology
2. Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice: August 10, 2021, Appears in: Communications Biology, Nature.com
3. SLACK Incorporated, “Current Insights About Constipation: October 2018
4. Phase III patients’ post research self-reported outcomes
5. Disruption of Circadian Rhythms and Gut Motility: Journal of Clinical Gastroenterology. May/June 2020 – Volume 54 – Issue 5 – p 405-414
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The Vibrant capsule is an investigational device limited to investigational use in the United States. It is currently under FDA review and is not available for sale.